Key Background Publications

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. P.H. Maxwell, M.S. Wiesener, G.-W. Chang, S.C. Clifford, E.C. Vaux, M.E. Cockman, C.C. Wykoff, C.W. Pugh, E.R. Maher, P.J. Ratcliffe. Nature 399 (1999) 271-275.

Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. P. Jaakkola, D.R. Mole, Y.M. Tian, M.I. Wilson, J. Gielbert, S.J. Gaskell, A. vonKriegsheim, H.F. Hebestreit, M. Mukherji, C.J. Schofield, P.H. Maxwell, C.W. Pugh, P.J. Ratcliffe. Science 292 (2001) 468-472.

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. A.C.R. Epstein, J.M. Gleadle, L.A. McNeill, K.S. Hewitson, J.F. O'Rourke, D.R. Mole, M. Mukherji, E. Metzen, M.I. Wilson, A. Dhanda, Y.M. Tian, N. Masson, D.L. Hamilton, P. Jaakkola, R. Barstead, J. Hodgkin, P.H. Maxwell, C.W. Pugh, C.J. Schofield, P.J. Ratcliffe. Cell 107 (2001) 43-54.

Structural basis for the recognition of Hydroxyproline in HIF-1α by pVHL. W.C. Hon, M.I. Wilson, K. Harlos, T.D. Claridge, C.J. Schofield, C.W. Pugh, P.H. Maxwell, P.J. Ratcliffe, D.I. Stuart, E.Y. Jones. Nature 417 (2002) 975-978.

HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron. S.J. Mandriota, K.J. Turner, D.R. Davies, P.G. Murray, N.V. Morgan, H.M. Sowter, C.C. Wykoff, E.R. Maher, A.L. Harris, P.J. Ratcliffe, P.H. Maxwell. Cancer Cell 1 (2002) 459-468.

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1α. J.M. Elkins, K.S. Hewitson, L.A. McNeill, J.F. Seibel, I. Schlemminger, C.W. Pugh, P.J. Ratcliffe, C.J. Schofield. J Biol Chem 278 (2003) 1802-1806.