Mukta Deobagkar

Mukta

I joined the Cornall lab in 2013 as a Postdoctoral Research Scientist. Using genetic and molecular approaches, I study the function of novel genes in B cell development, survival and selection. I am particularly interested in the molecular events involved in sensing signal quantity and quality and the subsequent decisions that govern lymphocyte fate.

I completed my BSc and MSc in Microbiology at the University of Pune in western India. I was funded by the CSIR (India) Shyama Prasad Mukherjee Fellowship for my PhD at the Department of Biochemistry, Indian Institute of Science, Bangalore in southern India. During my PhD, I studied the survival and activation of lymphocytes in the context of infection and host response mediated inflammation. 

Contact: Henry Wellcome Building for Molecular Physiology, Old Road Campus, Oxford, OX3 7BN. 

Email: mukta@well.ox.ac.uk

ORCID Profile: https://orcid.org/0000-0002-8543-6801

Do check out our retro "immune system in space" animation: https://www.youtube.com/watch?v=1TVJJ0HGOj4

 

Recent Publications:

  1. Xu X, Deobagkar-Lele M, Bull KR, Crockford TL, Mead AJ, Cribbs AP, Sims D, Anzilotti C, Cornall RJ. An ontogenetic switch drives the positive and negative selection of B cells. Proc Natl Acad Sci U S A. 2020 Feb 4. pii: 201915247. doi: 10.1073/pnas.1915247117. 
  2. Anzilotti C, Swan DJ, Boisson B, Deobagkar-Lele M, Oliveira C, Chabosseau P, Engelhardt KR, Xu X, Chen R, Alvarez L, Berlinguer-Palmini R, Bull KR, Cawthorne E, Cribbs AP, Crockford TL, Dang TS, Fearn A, Fenech EJ, de Jong SJ, Lagerholm BC, Ma CS, Sims D, van den Berg B, Xu Y, Cant AJ, Kleiner G, Leahy TR, de la Morena MT, Puck JM, Shapiro RS, van der Burg M, Chapman JR, Christianson JC, Davies B, McGrath JA, Przyborski S, Santibanez Koref M, Tangye SG, Werner A, Rutter GA, Padilla-Parra S, Casanova JL, Cornall RJ, Conley ME, Hambleton S. An essential role for the Zn2+ transporter ZIP7 in B cell development. Nat Immunol. 2019;20(3):350-361. doi: 10.1038/s41590-018-0295-8. 
  3. Ghezraoui H, Oliveira C, Becker JR, Bilham K, Moralli D, Anzilotti C, Fischer R, Deobagkar-Lele M, Sanchiz-Calvo M, Fueyo-Marcos E, Bonham S, Kessler BM, Rottenberg S, Cornall RJ, Green CM, Chapman JR. 53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ. Nature. 2018;560(7716):122-127. doi: 10.1038/s41586-018-0362-1.
  4. Deobagkar-Lele M, Anzilotti C, Cornall RJ. Themis2: setting the threshold for B-cell selection. Cell Mol Immunol. 2017;14(8):643-645. doi: 10.1038/cmi.2017.27. 
  5. Majumdar S, Deobagkar-Lele M, Adiga V, Raghavan A, Wadhwa N, Ahmed SM, Rananaware SR, Chakraborty S, Joy O, Nandi D. Differential susceptibility and maturation of thymocyte subsets during Salmonella Typhimurium infection: insights on the roles of glucocorticoids and Interferon-gamma. Sci Rep. 2017;7:40793. doi: 10.1038/srep40793.
  6. Cheng D*, Deobagkar-Lele M*, ZvezdovaE, Choi S, Lesourne R, Uehara S, Baup D, Bennett SC, Bull KR, CrockfordTL, Ferry H, Anzilotti C, Love PE*, Cornall RJ*. Themis2 lowers the threshold for B cell activation during positive selection. Nat Immunol. 2017;18(2):205-213. doi: 10.1038/ni.3642.
  7. Gautam R*, Deobagkar-Lele M*, Majumdar S, Chandrasekar B, Victor E, Ahmed SM, Wadhwa N, Verma T, Kumar S, Sundaresan NR, Umapathy S, Nandi D. Molecular profiling of sepsis in mice using Fourier Transform Infrared Microspectroscopy. J Biophotonics. 2016;9(1-2):67-82. doi: 10.1002/jbio.201400089.
  8. Siggs OM, Stockenhuber A*, Deobagkar-Lele M*, Bull KR, Crockford TL, Kingston BL, Crawford G, Anzilotti C, Steeples V, Ghaffari S, Czibik G, Bellahcene M, Watkins H, Ashrafian H, Davies B, Woods A, Carling D, Yavari A, Beutler B, Cornall RJ. Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity. Proc Natl Acad Sci USA. 2016;113(26):E3706-15. doi: 10.1073/pnas.1607592113. 
  9. Chandrasekar BS, Yadav S, Victor ES, Majumdar S, Deobagkar-Lele M, Wadhwa N, Podder S, Das M, Nandi D. Interferon-gamma and nitric oxide synthase 2 mediate the aggregation of resident adherent peritoneal exudate cells: implications for the host response to pathogens. PLoS One. 2015;10(6):e0128301. doi: 10.1371/journal.pone.0128301. 
  10. Deobagkar-Lele M, Victor ES, Nandi D. c-Jun NH2 -terminal kinase is a critical node in the death of CD4+ CD8+ thymocytes during Salmonella enterica serovar Typhimurium infection. Eur J Immunol. 2014;44(1):137-49. doi: 10.1002/eji.201343506.
  11. Deobagkar-Lele M, Chacko SK, Victor ES, Kadthur JC, Nandi D. Interferon-γ- and glucocorticoid-mediated pathways synergize to enhance death of CD4(+) CD8(+) thymocytes during Salmonella enterica serovar Typhimurium infection. Immunology. 2013;138(4):307-21. doi: 10.1111/imm.12047.
  12. Chandrasekar B, Deobagkar-Lele M, Victor ES, Nandi D. Regulation of chemokines, CCL3 and CCL4, by interferon γ and nitric oxide synthase 2 in mouse macrophages and during Salmonella enterica serovar Typhimurium infection. J Infect Dis. 2013;207(10):1556-68. doi: 10.1093/infdis/jit067. 
  13. Gautam R, Chandrasekar B, Deobagkar-Lele M, Rakshit S, Kumar BNV, Umapathy Sand Nandi D. Identification of Early Biomarkers during Acetaminophen-Induced Hepatotoxicity by Fourier Transform Infrared Microspectroscopy. PLoS One. 2012;c7(9):e45521. doi: 10.1371/journal.pone.0045521.
  14. Deobagkar-Lele M, Bhaskarla C, Dhanaraju R, Ponnusamy M, Nandi D. Innate Immunity and the 2011 Nobel Prize. Resonance. 2012; 17(10):974-95. doi: 10.1007/s12045-012-0111-y
  15. Ahmed A,Mukherjee S, Deobagkar M, Naik TandNandi D.Rapid burst of H2O2by plant growth regulators increases intracellular Ca2+amounts and modulates CD4+T cell activation. International Immunopharmacology. 2010;10 (11):1397-40. doi: 10.1016/j.intimp.2010.08.005.