Selected Publications

1.      Themis2 lowers the threshold for B cell activation during positive selection. Cheng D, Deobagkar-Lele M, Zvezdova E, Choi S, Uehara S, Baup D, Bennett SC, Bull KR, Crockford TL, Ferry H, Warzecha C, Marcellin M, de Peredo AG, Lesourne R, Anzilotti C, Love PE and Cornall RJ. Nat Immunol. 18:205-213, 2017.

2.      Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity. Siggs OM, Stockenhuber A, Deobagkar-Lele M, Bull KR, Crockford TL, Kingston BL, Crawford G, Anzilotti C, Steeples V, Ghaffari S, Czibik G, Bellahcene M, Watkins H, Ashrafian H, Davies B, Woods A, Carling D, Yavari A, Beutler B and Cornall RJ. Proc Natl Acad Sci U S A. 113: E3706-15, 2016.

3.      Mutation of the ER receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection. Siggs OM, Popkin DL, Krebs P, Li X, Tang M, Zhan X, Zeng M, Lin P, Xia Y, Oldstone MB, Cornall RJ and Beutler B. Proc Natl Acad Sci U S A. 112: E5706-14, 2015.

4.      Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations. Bull KR, Rimmer AJ, Siggs OM, Miosge LA, Roots CM, Enders A, Bertram EM, Crockford TL, Whittle B, Potter PK, Simon MM, Mallon AM, Brown SD, Beutler B, Goodnow CC, Lunter G, Cornall RJ. PLoS Genet. 9: e1003219. 2013.

5.      DOCK8 is critical for the survival and function of NKT cells. Crawford G, Enders A, Gileadi U, Stankovic S, Zhang Q, Lambe T, Crockford TL, Lockstone HE, Freeman A, Arkwright PD, Smart JM, Ma CS, Tangye SG, Goodnow CC, Cerundolo V, Godfrey DI, Su HC, Randall KL, Cornall RJ. Blood. 122:2052-61, 2013.

6.      Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production. Randall KL, Lambe T, Johnson A, Treanor B, Kucharska E, Domaschenz H, Whittle B, Tze LE, Enders A, Crockford TL, Bouriez-Jones T, Alston D, Cyster JG, Lenardo MJ, Mackay F, Deenick EK, Tangye SG, Chan TD, Camidge T, Brink R, Vinuesa CG, Batista FD, Cornall RJ* and Goodnow CC* (joint-senior and corresponding authors*).  Nat Immunol. 10:1283-91, 2009. (News and Views: B cell memory: how to start and when to end. Pelletier N, McHeyzer-Williams MG. Nat Immunol. 10:1233-., 2009)

7.      Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection. Johnson AL, Aravind L, Shulzhenko N, Morgun A, Choi SY, Crockford TL, Lambe T, Domaschenz H, Kucharska EM, Zheng L, Vinuesa CG, Lenardo MJ, Goodnow CC, Cornall RJ* and Schwartz RH*, (joint-senior and corresponding authors*).   Nat Immunol. 10:831-9, 2009.  (News and Views: Themis imposes new law and order on positive selection. Allen PM. Nat Immunol. 10:805-6, 2009 and Research Highlights: Themis in the thymusNature 460: 309-309, 2009.)

8.      Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome. Nijnik A, Dawson S, Crockford TL, Woodbine L, Visetnoi S, Bennett S, Jones M, Turner GD, Jeggo PA, Goodnow CC and Cornall RJ. J Clin Invest 119:1696-705. 2009.

9.      DNA repair is limiting for haematopoietic stem cells during ageing. Nijnik A, Woodbine L, Marchetti C, Dawson S, Lambe T, Liu C, Rodrigues NP, Crockford TL, Cabuy E, Vindigni A, Enver T, Bell JI, Slijepcevic P, Goodnow CC, Jeggo PA and Cornall RJ. Nature Article 447:686-90, 2007.  (News and Views: Ageing: from stem to stern.  Brunet A, Rando TA. Nature. 449:288-91, 2007)

10.   A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity.  Vinuesa CG, Cook MC, Angelucci C, Athanasopoulos V, Rui L, Hill KM, Yu D, Domaschenz H, Whittle B, Lambe T, Roberts IS, Copley RR, Bell JI, Cornall RJ and Goodnow CC. Nature Article 435:452-458, 2005.  

11.   Increased positive selection of B1 cells and reduced B cell tolerance to intracellular antigens in c1q-deficient mice. Ferry H, Potter PK, Crockford TL, Nijnik A, Ehrenstein MR, Walport MJ, Botto M, Cornall RJ. J Immunol 178:2916-22, 2007.

12.   CD4 T cell-dependent autoimmunity against a melanocyte neoantigen induces spontaneous vitiligo and depends upon Fas-Fas ligand interactions. Lambe T, Leung JC, Bouriez-Jones T, Silver K, Makinen K, Crockford TL, Ferry H, Forrester JV, Cornall RJ. J Immunol 177:3055-62, 2006.

13.   Signals from a self-antigen induce positive selection in early B cell ontogeny but are tolerogenic in adults. Ferry H, Crockford TL, Leung JC, Cornall RJ. J Immunol 176: 7402-11, 2006.

14.   The cellular location of self-antigen determines the positive and negative selection of autoreactive B cells.  Ferry H, Jones M, Vaux DJ, Roberts IS and Cornall RJ. J Exp Med. 198:1415-1425, 2003.

15.   Splenic T cell zone development is B cell dependent. Ngo VN, Cornall RJ, Cyster JG. J Exp Med. 194:1649-60, 2001.

16.   Role of Syk in B-cell development and antigen-receptor signaling.  Cornall RJ, Cheng AM, Pawson T, Goodnow CC. Proc Natl Acad Sci U S A. 97:1713-8, 2000.

17.   Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection.  Cornall RJ, Cyster JG, Hibbs ML, Dunn AR, Otipoby KL, Clark EA and Goodnow CC. Immunity 8:497-508, 1998.

18.   Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/Ity/Bcg genes on chromosome 1.  Cornall RJ, Prins JB, Todd JA, Pressey A, DeLarato NH, Wicker LS and Peterson LB. Nature Letter 353:262-265, 1991.

19.   Genetic analysis of autoimmune type 1 diabetes mellitus in mice. Todd JA, Aitman TJ, Cornall RJ, Ghosh S, Hall JR, Hearne CM, Knight AM, Love JM, McAleer MA, Prins JB, and et al. Nature Article 351:542-547, 1991. (News and Views: Genetics. Sweet mice, sugar daddies. Avner P. Nature. 351:519-20. 1991; and re-published as a “Pillar Article” by the Journal of Immunology, 193:7-12, 2014)

20.   The generation of a library of PCR-analyzed microsatellite variants for genetic mapping of the mouse genome. Cornall RJ, Aitman TJ, Hearne CM, Todd JA. Genomics 10:874-81, 1991.