Process of care and activity in a clinically inclusive ambulatory medical unit; progressive effect over time on clinical outcomes and acute medical admissions
Reschen ME, Bowen J, Singh S, Rajwani M, Giles M, Price J, Lasserson DS, O'Callaghan CA
Future Healthc J 2020; In press.

Cytoplasmic citrate flux modulates the immune stimulatory NKG2D ligand MICA in cancer cells. 
Moller SH, Mellergaard M, Madsen M, Bermejo AV, Jepsen SD, Hansen MH, Hogh RI, Aldana BI, Desler C, Rasmussen LJ, Sustarsic EG, Gerhart-Hines Z, Daskalaki E, Wheelock CE, Hiron TK, Lin D, O'Callaghan CA, Wandall HH, Andresen L, Skov S
Frontiers in Immunology 2020 doi: 10.3389/fimmu.2020.01968 In press. Article

Inosine pranobex enhances human NK cell cytotoxicity by inducing metabolic activation and NKG2D ligand expression.
McCarthy MT, Lin D, Soga T, Adam J, O'Callaghan CA
Eur J Immunol 2019 Aug 21. doi: 10.1002/eji.201847948 PubMed abstract Article

A genetics-led approach defines the drug target landscape of 30 immune-related traits.
Fang H, ULTRA-DD Consortium, De Wolf H, Knezevic B, Burnham KL, Osgood J, Sanniti A, Lledo Lara A, Kasela S, De Cesco S, Wegner JK, Handunnetthi L, McCann FE, Chen L, Sekine T, Brennan PE, Marsden BD, Damerell D, O'Callaghan CA, Bountra C, Bowness P, Sundstrom Y, Milani L, Berg L, Gohlmann HW, Peeters PJ, Fairfax BP, Sundstrom M, Knight JC
Nature Genetics 2019 Jul; 51(7):1082-1091.  PubMed abstract  Article

Prevalence of chronic kidney disease in the community in the United Kingdom in OxRen, a population-based cohort study
Hirst J, Hill N, O'Callaghan CA, Lasserson DS, McManus RJ, Ordonez Mena JM, Shine B, Taylore CJ, Vazquez-Montes M, Yang Y, Hobbs FDR
Br J Gen Pract 2020 Mar 26;70(693):e285-e293.  PubMed abstract

Statistical models for the deterioration of kidney function in a primary care population: A retrospective database analysis.
Oke JL, Feakins BG, Schlackow I, Mihaylova B, Simons C, O'Callaghan CA, Lasserson DS, Hobbs FDR, Perera R
F1000 Research 2019; 8:1618 ( Article

Effects of antihypertensives, lipid-modifying drugs, glycaemic control drugs and sodium bicarbonate on the progression of stages 3 and 4 chronic kidney disease in adults: a systematic review and meta-analysis.
Taylor KS, McLellan J, Verbakel JY, Aronson J, Lasserson DS, Pidduck n, Roberts N, Flemming S, O'Callaghan CA, Bankhead C, Banerjee A, Hobbs FDR, Perera R
BMJ Open 2019 Sep 20;9(9):e030596PubMed abstract

A retrospective analysis of outcomes in low and intermediate-high risk pulmonary embolism patients managed on an ambulatory medical unit in the UK.
Reschen ME, Raby J, Bowen J, Singh S, Lasserson D, O'Callaghan CA
European Respiratory Journal Open Research 2019 Apr 8;5(2). pii: 00184-2018; PubMed abstract

Reduced kidney function at presentation in unselected acute emergency medical admissions: incidence, outcome and associated factors
Yang E, Chalisey A, Reschen ME, Shine B, Lasserson DS, O'Callaghan CA
Acute Medicine 2019 Sept; 18(3):158-164. PubMed abstract See accompanying editorial

Trends in kidney function testing in UK primary care since the introduction of the quality and outcomes framework: a retrospective cohort study using CPRDD.
Feakins B, Oke J, McFadden E, Aronson J, Lasserson D, O'Callaghan CA, Taylor C, Hill N, Stevens R, Perera R
BMJ Open 2019; 9:e028062-e028062; PubMed abstract  Article

Dexi disruption depletes gut microbial metabolites and accelerates autoimmune diabetes.
Davison LJ, Wallace MD, Preece C, Hughes K, Todd JA, Davies B, O'Callaghan CA
BioRxiv 2018 August 16; 393421; Article

Intragenic transcriptional interference regulates the human immune ligand MICA.
Lin D, Hiron TK, O'Callaghan CA
EMBO Journal 2018 May 15;37(10). pii: e97138. PubMed abstract  Article

Metclo: methylase-assisted hierarchical DNA assembly using a single type IIS restriction enzyme.
Lin D and O'Callaghan CA
Nucleic Acid Research 2018 Nov 2;46(19):e113 doi: 10.1093/nar/gky596; 

Purine nucleotide metabolism regulates expression of the human immune ligand MICA.
McCarthy MT, Moncayo G, Hiron TK, Jakobsen NA, Valli A, Soga T, Adam J, O'Callaghan CA
J Biol Chem 2018 Mar 16;293(11):3913-3924 PubMed abstract Article J Biol Chem Immunometabolism collection

Pathogen-derived HLA-E bound epitopes reveal braod primary anchor pocket tolerability and conformationally malleable peptide binding.
Walters L, Harlos K, Brackenridge S, Rozbesky D, Barrett J, Jain V, Walter T, O'Callaghan CA, Borrow P, Toebes M, Hansen S, Sacha J, Abdulhaqq S, Green J, Frueh K, Marshall E, Picker L, Jones E, McMichael AJ, Gillespie G
Nature Communications 2018 Aug 7;9(1):3137doi: 10.1038/s41467-018-05459-z  

Spanish adaptation of the free OxMaR software for minimization and randomization of clinical studies.
Guillaumes S and O'Callaghan CA
Gaceta Sanitaria 2019 Jul - Aug;33(4):395-397.

Activation of the Immune-Metabolic Receptor GPR84 Enhances Inflammation and Phagocytosis in Macrophages.
Recio C, Lucy D, Purvis G, Iveson P, Zeboudj L, Iqbal AJ, Lin D, O'Callaghan CA, Davison L, Griesbach E, Russell A, Wynne G, Dib L, Monaco C, Greaves D
Front Immunol 2018 June 20; doi: 10.3389/fimmu.2018.01419  Article

The Role of Metabolite-sensing G Protein-Coupled Receptors in inflammation and metabolic disease.
Recio C, Iqbal AJ, Valaris S, Lucy D, Wynne G, Russell AJ, Choudhury R, O'Callaghan CA, Monaco C, Greaves DR.
Antioxidants and Redox Signalling 2018 Jan 17. doi: 10.1089/ars.2017.7168. PubMed abstract

Systematic Review and Meta-analysis Comparing the Bias and Accuracy of the Modification of Diet in Renal Disease and Chronic Kidney Disease Epidemiology Collaboration Equations in Community-Based Populations.
McFadden EC, Hirst JA, Verbakel JY, McLellan JH, Hobbs FDR, Stevens RJ, O'Callaghan CA, Lasserson DS
Clin Chem. 2018 Mar;64(3):475-485. doi: 10.1373/clinchem.2017.276683. PubMed abstract Article

Mouse podoplanin supports adhesion and aggregation of platelets under arterial shear: a novel mechanism of haemostasis.
Lombard SE, Pollitt AY, Hughes CE, Di Y, McKinnon T, O’Callaghan CA, Watson SP.
Platelets 2018 Nov;29(7):716-722. doi: 10.1080/09537104.2017.1356919. PubMed abstract

Requirement for cystatin C testing in chronic kidney disease: retrospective population-based study.
Lasserson DS, Shine B, O’Callaghan CA, James T.
Br J Gen Pract. 2017  Oct;67(663):e732-e735. doi: 10.3399/bjgp17X692585. PubMed abstract Article

Genetic and environmental risk factors for atherosclerosis regulate transcription of phosphatase and actin regulating gene PHACTR1.
Reschen ME, Lin D, Chalisey A, Soilleux EJ, O'Callaghan CA
Atherosclerosis. 2016 May 2;250:95-105. PubMed abstract Article 

MICA expression is regulated by cell adhesion and contact in a FAK/Src dependent manner.
Moncayo G, Lin D, McCarthy MT, Watson AA, O'Callaghan CA
Front Immunol. 2017 Jan 19;7:687. doi: 10.3389/fimmu.2016.00687 PubMed abstract Article 

A deletion in the canine POMC gene, linked to obesity in Labrador retrievers, is not associated with increased susceptibility to diabetes mellitus in this breed.
Davison LJ, Holder A, Catchpole B, O’Callaghan CA
Journal of Veterinary Internal Medicine 2017 Feb 8. doi: 10.1111/jvim.14636. PubMed abstract 

What is the relationship between renal function and visit-to-visit blood pressure variability in primary care? Retrospective cohort study from routinely collected healthcare data.
Lasserson DS, Scherpbier de Haan N, de Grauw W, van der Wel, M, Wetzels JF, O'Callaghan CA.
BMJ Open. 2016 Jun 10;6(6):e010702. PubMed abstract Article 

Structure of non-classical MHC I (HLA-E, HLA-F, HLA-G and orthologs).
O'Callaghan CA
Encyclopedia of Immunobiology, Vol. 2, pp. 178-189.
Section Editor: Elliot T, Editor: Ratcliffe MJH
Academic Press, Elsevier, Oxford, 2016 View online

Global prevalence of Chronic Kidney Disease - A systematic review and meta-analysisof primary care in managing chronic kidney disease.
Hill NR, Fatoba ST, Oke JL, Hirst JA, O’Callaghan CA, Lasserson DS, Hobbs FDR
PLOS ONE. 2016 Jul 6;11(7):e0158765 PubMed abstract 

The role of primary care in managing chronic kidney disease.
Maycock AJ and O'Callaghan CA.
Prescriber. 2016. May; 27(5):34-37. 

Genetic fine-mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. 
DIAGRAM Consortium
Nature Genetics. 2015 Dec;47(12):1415-25; doi:10.108/ng.3437. PubMed abstract Article

Lipid-induced epigenomic changes in human macrophages identify a coronary artery disease associated variant that regulates PPAP2B expression through altered C/EBP-beta binding.
Reschen ME, Gaulton KJ, Lin D, Soilleux EJ, Morris AJ, Smyth SS, O'Callaghan CA
PLOS Genetics. 2015 Apr 2;11(4):e1005061. PubMed abstract Article

Activation of Glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands.
Alsehri O, Montague S, Watson S, Carter P, Sarker N, Manne B, Miller JLC, Herr AB, Pollitt AY, O'Callaghan CA, Kunapuli S, Arman M, Hughes CE, Watson SP.
Biochem J. 2015 Jun 15;468(3):459-73. PubMed abstract

Analysis of EBOLA entry into macrophages.
Dahlmann F, Biedenkopf N, Babler A, Jahnen-Dechent W, Karsten C, Grirss K, Schneider H, Wrensch F, O'Callaghan CA, Bertram S, Herrler G, Becker S, Pohlmann S, Hofmann H.
J Infect Dis. 2015 Apr 14. pii: jiv140. PubMed abstract

Establishing an infrastructure to support the development and delivery of clinical research in patients with kidney disease. 
UK Kidney Research Consortium
Clinical Medicine. 2015 Oct 5;15(5):415-9. doi: 10.7861/clinmedicine.15-5-415. PubMed abstract

OxMaR: open source free software for online minimization and randomization for clinical trials.
O'Callaghan CA.
PLOS ONE. 2014 Oct 29;9(10):e110761. PubMed abstract Article

PeaKDEck: a kernel density estimator-based peak calling program for DNaseI-seq data.
McCarthy MT and O'Callaghan CA.
Bioinformatics. 2014 May 1;30(9):1302-4. PubMed abstract Download program Article

Prevention of organ rejection in renal and liver transplantation with extended release tacrolimus.
Reschen ME and O'Callaghan CA.
Transplant Research and Risk Management. 2014 Sept 2;6:55-72. Article

Solid phase platereader quantification of specific PCR products by measurement of band-specific ethidium bromide fluorescence.
McCarthy MT and O'Callaghan CA.
Analytical Biochemistry. 2014 Feb 15;447:30-32. PubMed abstract

Immunological monitoring of the kidney transplant recipient.
Chakera A and O'Callaghan CA.
Chapter 22, pp 475-496; In The Complex Evolution of Kidney Transplantation, Organ Transplant Research Horizons, Nova Science Publishers, New York; 2014

The Oxford Renal Cross-Sectional Study – Protocol.
Hill RN, Lasserson DS, Fatoba S, O'Callaghan CA, Pugh CW, Perera-Salazar R, Shine B, Thompson B, Wolstenholme J, McManus R, Hobbs R.
BMJ Open. 2013 Dec 17;3(12):e004265. Pubmed abstract

Impact on cardiovascular risk follow-up from a shift to the CKD-EPI formula for eGFR reporting: a cross sectional population-based primary care study.
van Gelder VA, Scherpbier-de Haan ND, de Grauw WJC, O'Callaghan CA, Wetzels JFM, Lasserson DS.
BMJ Open. 2013 Sep 25(9); 3:e003631 Pubmed abstract

Critical role for an acidic amino acid region in platelet signalling by the hemITAM (hemi-Immunoreceptor Tyrosine-based Activation Motif) containing receptor CLEC-2 (C-type Lectin receptor-2).
Hughes CE, Sinha U, Pandey A, Eble JA, O'Callaghan CA, Watson SP.
J Biol Chem. 2013 Feb 15;288(7):5127-35.  Pubmed abstract

Floating-Harbor Syndrome and polycystic kidneys associated with SRCAP mutation.
Reschen M, Kini U, Hood RL, Boycott KM, Hurst J, O'Callaghan CA.
Am J Med Genet. 2012 Nov 19;158(12):3196-3200. Epub 2012 Nov 19. Pubmed abstract

NF-kappa B regulates MICA transcription in endothelial cells through a genetically inhibitable control site.
Lin D, Lavender H, Soilleux E, O'Callaghan CA.
J Biol Chem. 2012 Feb 3;287(6):4299-310. Pubmed abstract

Structural flexibility of the macrophage dengue virus receptor CLEC5A:Implications for ligand binding and signaling.
Watson AA, Lebedev AA, Hall BA, Fenton-May AE, Vagin AA, Dejnirattisai W, Mongkolsapaya J, Felce J, Palma AS, Liu Y, Feizi T, Screaton GR, Murshudov GN, O'Callaghan CA.
J Biol Chem. 2011 Jul 8;286(27):24208-18.
Pubmed abstract Faculty of 1000 listing

Chronic kidney disease: a large scale population-based study of the effects of introducing the CKD-EPI formula for eGFR reporting.
O'Callaghan CA, Shine B, Lasserson DS.
BMJ Open 2011 Dec 19;1(2):e000308. doi:10.1136/bmjopen-2011-000308 Pubmed abstract  Journal

Biology - the path ahead.
O'Callaghan CA
Biology 2011 Sep 1; 1(1), 1-4. Journal

Expression, purification and crystallization of the human UL16-binding protein ULBP1.
Watson AA, Christou CM, O'Callaghan CA.
Protein Expression and Purification 2011 Sep 1;79(1):44-48. Pubmed abstract

Molecular analysis of the interaction of the snake venom rhodocytin with the platelet receptor CLEC-2.
Watson AA and O'Callaghan CA
Toxins 2011 Aug 10; 3(8), 991-1003. Pubmed abstract  Pubmed Central Journal

Antigen-specific T-cell responses to BK polyomavirus antigens identifies functional antiviral immunity and may help guide immunosuppression following renal transplantation.
Chakera A, Bennet S, Lawrence S, Morteau O, Mason PD, O'Callaghan CA, Cornall RJ
Clin Exp Immunol 2011 Sep;165(3):401-9. Pubmed abstract 

Recognition and Blocking of Innate Immunity Cells by Candida albicans Chitin.
Mora-Montes HM, Netea MG, Ferwerda G, Lenardon MD, Brown GD, Mistry AR, Kullberg BJ, O'Callaghan CA, Chirag C. Sheth CC, Odds FC, Brown AJP, Munro CA, Gow NAR.
Infect Immun. 2011 May;79(5):1961-70. Pubmed abstract

Renal transplant immunosuppression impairs natural killer cell function in vitro and in vivo.
Morteau O, Blundell S, Chakera A, Bennett, S, Christou CM, Mason PD, Cornall RJ, O'Callaghan CA.
PLOS ONE. 2010 Oct 12;5(10). pii: e13294. doi:10.1371/journal.pone.0013294 Pubmed abstract

Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations.
Antoun A, Jobson S, Cook M, O’Callaghan CA, Moss PAH, Briggs DC.
Hum Immunol. 2010 Jun;71(6):610-620. Pubmed abstract

A lucky fall?
Chakera A, Leslie T, Roberts I, O’Callaghan CA, Cranston D.
Transplant Proc. 2010 Nov;42(9):3883-6. Pubmed abstract

CLEC-2 activates Syk through dimerisation.
Hughes CE, Pollitt AY, Mori J, Eble J, Tomlinson MG, Hartwig JH, O’Callaghan CA, Futterer K, Watson SP.
Blood. 2010 Apr 8;115(14):2947-55. Pubmed abstract

Reversible renal impairment caused by thyroid disease.
Chakera A, Hans-Joerg P, O’Callaghan CA.
Scandinavian Journal of Urology and Nephrology. 2010 Apr;44(3):190-2. Pubmed abstract

Watson AA and O'Callaghan CA
UCSD-Nature Molecule Pages 2009; doi:10.1038/mp.a004147.01

Crystallization and X-ray diffraction analysis of human CLEC5A (MDL-1) - a Dengue virus receptor.
Watson AA and O’Callaghan CA.
Acta Crystallograph Sect F Struct Biol Cryst Commun. 2009 Dec 25;66(Pt 12):29-31. Pubmed abstract

The Platelet Receptor CLEC-2 is Active as a Dimer.
Watson AA, Christou CM, James JR, Fenton-May AE, Moncayo GE, Mistry AR, Davis SJ, Gilbert RJ, Chakera, A, O’Callaghan CA.
Biochemistry. 2009 Nov 24;48(46):10988-96. Pubmed abstract

The hyponatraemic hairdresser: highlighting the differentials.
Herrington W, Allmossawi H, Roberts SDI, O’Callaghan CA.
The Lancet 2009 Oct;374(9698) 1392. Pubmed abstract    Manuscript

Mistry AR and O'Callaghan CA
UCSD-Nature Molecule Pages 2009; doi:10.1038/mp.a004148.01

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP.
Bishop B, Aricescu AR, Harlos K, O'Callaghan CA, Jones EY, Siebold C
Nature Structural & Molecular Biology 2009 Jul;16(7):698-703. Pubmed abstract

O'Callaghan CA
UCSD-Nature Molecule Pages 2009; doi:10.1038/mp.a001666.01

Chronic Kidney Disease - assessing the impact
O'Callaghan CA
Quarterly Journal of Medicine 2009 Jun;102(6):431-3. Pubmed abstract

Thrombomodulation via CLEC-2 targeting.
O'Callaghan CA
Current Opinion in Pharmacology 2009 Apr;9(2):90-5. Pubmed abstract   doi

Kidney Transplantation - the long term view
O'Callaghan CA
Quarterly Journal of Medicine 2008 Dec;101(12):985-6. Pubmed abstract   doi   PDF

O'Callaghan CA and Watson SP
UCSD-Nature Molecule Pages 2008; doi:10.1038/mp.a004057.01

Crystal structure of rhodocytin, a ligand for the platelet-activating receptor CLEC-2.
Watson AA, Eble JA, O'Callaghan CA
Protein Science 2008 Sep;17(9):1611-6. Pubmed abstract

Renal cells activate the platelet receptor CLEC-2 through podoplanin.
Christou CM, Pearce AC, Watson AA, Mistry AR, Pollitt AY, Fenton-May AE, Johnson LA, Jackson DG, Watson SP, O'Callaghan CA
Biochem J. 2008 Apr 1;411(1):133-140. Pubmed abstract

Regulation of ligands for the activating receptor NKG2D.
Mistry AR and O'Callaghan CA
Immunology. 2007 August;121(4):439-447. Pubmed abstract

The crystal structure and mutational binding analysis of the extracellular domain of the platelet activating receptor CLEC-2.
Watson AA, Brown J, Harlos K, Eble JA, Walter TS, O'Callaghan CA
J Biol Chem. 2007 Feb 2;282(5):3165-3172. Pubmed abstract

Structure of the fungal beta-glucan-binding immune receptor dectin-1: implications for function.
Brown J, O'Callaghan CA, Marshall ASJ, Gilbert RJC, Siebold C, Gordon S, Brown GD and Jones EY.
Protein Sci. 2007 Jun;16(6):1042-52. Pubmed abstract

Defining the T cell antigen proteome of wasp venom.
Aslam A, Kessler B, Batycka M, O'Callaghan CA, Misbah SA, Warrell DA and Ogg G
Clin Exp Allergy. 2006 Oct;36(10):1274-80. Pubmed abstract

The structure of the human allo-ligand HLA-B*3501 in complex with a cytochrome P450 peptide: steric hindrance influences TCR allo-recognition.
Hourigan CS, Harkiolaki M, Peterson NA, Bell JI, Jones EY and O'Callaghan CA
Eur J Immunol. 2006 Dec;36(12):3288-93. Pubmed abstract

Renal manifestations of systemic autoimmune disease: diagnosis and therapy.
O'Callaghan CA
Nephrol Ther. 2006 Jul;2(3):140-51. Pubmed abstract

Crystallization and X-ray diffraction analysis of human CLEC-2.
Watson AA and O'Callaghan CA
Acta Crystallograph Sect F Struct Biol Cryst Commun. 2005 Dec 1;61(Pt 12):1094-6. Pubmed abstract

Renal manifestations of systemic autoimmune disease: diagnosis and therapy.
O'Callaghan CA
Best Pract Res Clin Rheumatol. 2004 Jun;18(3):411-27. Pubmed abstract

Structural and Energetic Aspects of Multispecific Immune Recognition by NKG2D.
O'Callaghan CA, and Jones EY.
Structure 2003 Apr;11(4):360-1. Pubmed abstract

Cutting Edge: The Minor Histocompatibility Antigen H60 Peptide binds to both H-2Kb and NKG2D.
Cerwenka A, O'Callaghan CA, Hamerman J, Joyce S, Yadav R, Ajayi W, Roopenian DC, Joyce S, Lanier LL
J Immunol 2002 Apr 1;168 3131-3134. Pubmed abstract

Direct visualisation of cytomegalovirus-specific CD8+ T cells in renal transplant patients.
Hilton RM, Hargreaves RE, Sacks SH and O'Callaghan CA
Transplant Proc 2002 Jun;34(4):1171-3. Pubmed abstract

Characteristics and outcome of membranous nephropathy in older patients.
O'Callaghan CA, Hicks J, Doll H, Sacks SH, Cameron JS
Int Urol Nephrol 2002; 33 (1): 157-165. Pubmed abstract

Tetrameric complexes of HLA-E, HLA-F, and HLA-G.
Allan D, Lepin E, Braud V, O'Callaghan CA, McMichael A.
J Immunol Methods 2002 Oct 1;268(1):43. Pubmed abstract

Molecular competition for NKG2D: H60 and RAE1 compete unequally for NKG2D with dominance of H60.
O'Callaghan CA, Cerwenka A, Willcox BE, Lanier LL, Bjorkman PJ.
Immunity 2001 Aug;15(2):201-11. Pubmed abstract

Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors.
Lepin EJM, Bastin JM, Allan DSJ, Roncador G, Braud VM, Mason DY, van der Merwe PA, McMichael AJ, Bell JI, Powis SH, O'Callaghan CA.
Eur J Immunol 2000 December;30(12):3552-3561. Pubmed abstract

Natural Killer cell surveillance of intracellular antigen processing pathways mediated by recogniton of HLA-E and Qa-1b by CD94/NKG2 receptors.
O'Callaghan CA
Microbes and Infection 2000 Apr;2(4):371-80.Pubmed abstract

Classical and Nonclassical Class I Major Histocompatibility Complexp Molecules Exhibit Subtle Conformational Differences That Affect Binding to CD8alpha-alpha
Gao GF, Willcox BE, Wyer JR, Boulter JM, O'Callaghan CA, Maenaka K, Stuart DI,Jones EY, Van Der Merwe PA, Bell JI, and Jakobsen BK.
J. Biol. Chem 2000 275: 15232-15238. Pubmed abstract

Molecular basis of human natural killer cell recognition of HLA-E (human leucocyte antigen-E) and its relevance to clearance of pathogen-infected and tumour cells.
O'Callaghan CA
Clin Sci.2000 Jul 1;99(1):9-17. Pubmed abstract

Recombinant modified vaccinia virus Ankara efficiently restimulates human cytotoxic T lymphocytes in vitro.
Dorrell L, O'Callaghan CA, Britton W, Hambleton S, McMichael A, Smith GL, Rowland-Jones S, Blanchard TJ
Vaccine2000 Sep 15;19(2-3):327-336.Pubmed abstract

Functional Heterogeneity and High Frequencies of Cytomegalovirus-Specific CD8(+) T Lymphocytes in Healthy Seropositive Donors.
Gillespie GM, Wills MR, Appay V, O'Callaghan CA, Murphy M, Smith N, Sissons P, Rowland-Jones S, Bell JI, Moss PA.
J Virol2000 Sep 1;74(17):8140-8150.Pubmed abstract

Differential Narrow Focusing of Immunodominant Human Immunodeficiency Virus Gag-Specific Cytotoxic T-Lymphocyte Responses in Infected African and Caucasoid Adults and Children.
Goulder PJ, Brander C, Annamalai K, Mngqundaniso N, Govender U, Tang Y, He S, Hartman KE, O'Callaghan CA, Ogg GS, Altfeld MA,Rosenberg ES, Cao H, Kalams SA, Hammond M, Bunce M, Pelton SI, Burchett SA, McIntosh K, Coovadia HM, Walker BD,
J Virol. 2000 Jun 15;74(12):5679-5690. Pubmed abstract

Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes.
Oxenius A, Price DA, Easterbrook PJ, O'Callaghan CA, Kelleher AD, Whelan JA, Sontag G, Sewell AK, Phillips RE
Proc Natl Acad Sci U S A 2000 Mar 28;97(7):3382-7 Pubmed abstract

Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children.
Goulder PJ, Tang Y, Brander C, Betts MR, Altfeld M, Annamalai K, Trocha A, He S, Rosenberg ES, Ogg G, O'Callaghan CA, Kalams SA, McKinney RE Jr, Mayer K, Koup RA, Pelton SI, Burchett SK, McIntosh K, Walker BD
J Exp Med 2000 Dec 18;192(12):1819-1832. Pubmed abstract

BirA enzyme: Production and application in the study of membrane receptor-ligand interactions by site specific biotinylation.
O'Callaghan CA, Byford MF, Wyer JR, Willcox BE, Jakobsen BK, McMichael AJ, and Bell JI.
Analytical Biochemistry. 1999 Jan 1;266(1):9-15. Pubmed abstract

Cutting Edge: HLA-B27 forms a stable homodimer structure that can bind peptide in the absence of beta 2 microglobulin.
Allen RL, O'Callaghan CA, McMichael AJ, and Bowness P.
J Immunol 1999 May 1;162(9):5045-8. Pubmed abstract

Production of soluble alpha-beta T-cell receptor heterodimers suitable for biophysical analysis of ligand binding.
Willcox BE, Gao GF, Wyer JR, O'Callaghan CA, Boulter JM, Jones EY, van der Merwe PA, Bell JI, Jakobsen BK
Protein Science 1999 Nov;8(11):2418-23 Pubmed abstract

A re-evaluation of the frequency of cytotoxic T cells specific for Epstein-Barr virus in healthy virus carriers.
Tan LC, Gudgeon N, Annels N, Hansasuta P, O'Callaghan CA, Rickinson AB, McMichael AJ, and Callan MFC.
J Immunol 1999 Feb 1;162(3):1827-35. Pubmed abstract

Changes in frequency of HIV-1 specific CTL precursors and circulating effectors after combination antiretroviral therapy in children.
Spiegel HML, DeFalcon E, Ogg GS, Larsson M, Beadle T, Tao P, McMichael AJ, Bhardway N, O'Callaghan CA, Cox WI, Krasinski K, Pollack H, Borkowsky W, Nixon DF.
J Infect Dis 1999 Aug;180(2):359-68. Pubmed abstract

Cytotoxic T lymphocytes and viral evolution in primary HIV-1 infection.
Price DA, O'Callaghan CA, Whelan JA, Easterbrook PJ, Phillips RE
Clinical Science 1999 Dec 1;97(6):707-718 Pubmed abstract

Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E.
O'Callaghan CA, Tormo J, Willcox BE, Braud VM, Jakobsen BK, Stuart DI, McMichael AJ, Bell JI, Jones EY
Molecular Cell 1998 Mar;1(4):531-41 Pubmed abstract

Production, crystallization and preliminary x-ray analysis of the human class Ib MHC molecule HLA-E.
O'Callaghan CA, Tormo J, Willcox BE, Blundell CD, Jakobsen BK, Stuart DI,McMichael AJ, Bell JI, and Jones EY.
Protein Science 1998; May 7(5): 1264-1266. Pubmed abstract

HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C.
Braud V, Allan DSJ, O'Callaghan CA, Ogg GS, Lazetic S, Young NT, Bell JI,Phillips JH, Lanier LL, and McMichael AJ.
Nature. 1998 Feb 19;391(6669):795-9. Pubmed abstract

Structure and function of the human MHC class Ib molecules HLA-E, HLA-F and HLA-G.
O'Callaghan CA and Bell JI.
Immunological Reviews. 1998 Jun;163:129-38. Pubmed abstract

A new look at T cells.
McMichael AJ, and O'Callaghan CA
J Exp Med 1998 May 4;187(9):1367-71. Pubmed abstract

Direct visualisation of antigen-specific CD8+ T cells during the primary immune response to Epstein Barr virus in vivo.
Callan MFC, Tan L, Annels N, Ogg GS, Wilson JDK, O'Callaghan CA, McMichael AJ, and Rickinson AB.
J Exp Med 1998 May 4;187(9):1395-402. Pubmed abstract

Cutting Edge: Human myelomonocytic cells express an inhibitory receptor for classical and non-classical MHC class I molecules.
Colonna M, Samaridis J, Cella M, Angman L, Allen R, O'Callaghan CA, Dunbar R, Ogg G, Cerundolo V, and Rolink A.
J Immunol 1998 Apr 1;160(7):3096-100. Pubmed abstract

Oligoclonal expansions of CD8+ T cells in chronic HIV infection are antigen specific.
Wilson JDK, Ogg GS, Allen RL, Goulder PJ, Kelleher T, Sewell A, O'Callaghan CA, Callan MFC, Rowland-Jones SL, and McMichael AJ.
J Exp Med 1998 Aug 17;188(4):785-90. Pubmed abstract

Kupffer cell staining by an HFE specific monoclonal antibody - implications for hereditary haemochromatosis.
Bastin JM, Jones M, O'Callaghan CA, Schimanski L, Mason DY, and Townsend ARM.
Br J Haematol 1998 Dec;103(4):931-41. Pubmed abstract

Assembly and crystallization of the complex between the human T cell coreceptor CD8 alpha-alpha dimer and HLA-A2.
Gao G, Gerth U, Wyer J, Willcox BE, O'Callaghan CA, Jones EY, Stuart DI, Bell JI, and Jakobsen BK.
Protein Science 1998 May;7(5):1245-9. Pubmed abstract

Engagement of a T cell receptor by major histocompatibility complex irrespective of peptide.
Vessey SJR, Barouch DH, McAdam SN, Tussey LG, Davenport MA, O'Callaghan CA, Bell JI, McMichael AJ, and Jakobsen BK.
Eur J Immunol 1997 Apr;27(4):879-85. Pubmed abstract

Combined structural and immunological refinement of HIV-1 HLA-B8 restricted cytotoxic T lymphocyte epitopes.
Goulder PJR, Reid SW, Price DA, O'Callaghan CA, McMichael AJ, Phillips RE, and Jones EY.
Eur J Immunol 1997 Jun;27(6):1515-21. Pubmed abstract

Antagonist HIV-1 Gag peptides induce structural changes in HLA B8.
Reid SW, McAdam S, Smith KJ, Klenerman P, O'Callaghan CA, Harlos K, Jakobsen BK, McMichael AJ, Bell JI, Stuart DI, and Jones EY.
J Exp Med 1996 Dec 1;184(6):2279-86. Pubmed abstract

Production and crystallization of MHC class I B allele single peptide complexes.
Reid SW, Smith KJ, Jakobsen BK, O'Callaghan CA, Reyburn H, Harlos K, Stuart DI, McMichael AJ, Bell JI, and Jones EY.
FEBS Letters 1996 Mar 25;383(1-2):119-23. Pubmed abstract

Accumulation of a furan propanoic dicarboxylic acid (3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid) is related to neurological abnormalities in patients with renal failure.
Costigan MG, O'Callaghan CA, and Lindup WE.
Nephron 1996;73(2):169-73. Pubmed abstract

Early prediction of treatment outcome in idiopathic membranous nephropathy.
O'Callaghan CA, Cameron JS, and Sacks SH.
Q J Med 1995 Dec;88(12):889-94. Pubmed abstract

Prolonged QT syndrome presenting as epilepsy.
O'Callaghan CA, and Trump D.
Lancet 1993 Mar 20;341(8847):759-60. Pubmed abstract

Topical non-steroidal anti-inflammatory drugs and renal disease.
O'Callaghan CA
Biomedicine and Pharmacotherapy 1995 49(4):219.

Effective use of cyclosporin in sarcoidosis: a treatment strategy based on computed tomography scanning.
O'Callaghan CA, Wells AU, Lalvani A, Dhillon PD, Hansell DM, and Mitchell DN.
Eur Resp J 1994 Dec;7(12):2255-6. Pubmed abstract

Renal disease and use of topical non-steroidal anti-inflammatory drugs.
O'Callaghan CA, Andrews PA, and Ogg CS.
British Medical Journal 1994 Jan 8;308(6921):110-1. Pubmed abstract

Acute arsenic poisoning: absence of polyneuropathy with 2,3 dimercaptopropanesulphonate (DMPS).
Moore DF, O'Callaghan CA, Berlyne G, Ogg CS, Alban Davies H, House IM, and Henry JA.
J Neurology, Neurosurgery and Psychiatry 1994 Sep;57(9):1133-5. Pubmed abstract

Non-steroidal anti-inflammatory drugs in the postoperative period: many factors threated renal function.
O'Callaghan CA, Andrews PA, and Ogg CS.
British Medical Journal 1993 Jul 24;307(6898):257 Pubmed abstract

Acute renal failure associated with NSAIDs.
O'Callaghan CA.
British Medical Journal 1994 Mar 26;308(6932):857-8. Pubmed abstract

Prevention of nosocomial respiratory syncytial virus infection.
O'Callaghan CA.
Lancet 1993 Jan 16;341(8838):182 Pubmed abstract

Handwashing and cohorting prevent hospital acquired infections with respiratory syncitial virus.
Isaacs D, Dickson H, O'Callaghan CA, Sheaves R, Winter A, and Moxon R.
Arch Dis Childhood 1991 Feb;66(2):227-31. Pubmed abstract


The MRCP part 1:a system based tutorial.
O'Callaghan CA
First Edition. 1997. Oxford:Blackwells Science UK.

The Kidney at a glance.
O'Callaghan CA and Brenner BM
First Edition 2000 Oxford: Blackwells Science UK and Boston, USA
(Chinese and Greek translations)

The Renal system at a Glance
O'Callaghan CA
Second Edition (of The Kidney at a Glance) January 2006 Oxford: Blackwell-Wiley UK.
(Japanese, Russian, Indonesian, Spanish and Greek translations)

The Renal system at a Glance
O'Callaghan CA
Third Edition 2009. Oxford: Wiley-Blackwell UK.
(Chinese and Greek translations)

The Renal system at a Glance
O'Callaghan CA
Fourth Edition 2017. Oxford: Wiley-Blackwell UK.

Royal College of Physicians MRCP Medical Masterclass: Nephrology
Fluck N, Kalra P, Maxwell P, O'Callaghan CA (ed. Maxwell P)
First edition 2001 Royal College of Physicians Press and Blackwells Science
- Second edition 2008

Medicine. Second Edition
Editors: Axford J and O'Callaghan CA
Oxford : Blackwell Publications 2004
A major international textbook of medicine.

Hypertension and Nephrology
Hill P and O'Callaghan CA
Chapter in 'An Insider's Guide to the Medical Specialties.' Editors: Reckless I and Reynolds J, Oxford University Press 2006

Renal Medicine
Chakera A, Herrington W and O'Callaghan CA
Renal chapters in 'Oxford Diagnosis and Treatment in Internal Medicine'
Editors: Davey P and Sprigings D,
Oxford University Press, 2018

The Oxford Dictionary of Biomedicine
Editor: Lackie J; Advisory Editor: O'Callaghan CA
Oxford University Press, 2010

Renal Function
O'Callaghan CA
Chapter 9.1 pp 1027-1039 in 'The Oxford Textbook of Urological Surgery', Editor: F. Hamdy
Oxford University Press 2018